PE 22-28 (10mg)

PE-22-28 (Neuroprotective Peptide / Adrenocorticotropic Fragment Analog)

Molecular Formula: C₄₆H₆₄N₁₀O₁₂
Molecular Weight: 933.07 g/mol
Sequence: Val-Gly-Arg-Pro-Lys-Val-Gly-Pro
CAS Number: 63958-90-7 (commonly referenced for the ACTH fragment 22-28)
Purity: ≥98 % (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

PE-22-28 is a synthetic octapeptide fragment (amino acids 22–28) derived from adrenocorticotropic hormone (ACTH).
This peptide represents a neuroactive and neurotrophic sub-sequence of the ACTH molecule that retains neuromodulatory and cytoprotective properties without classical corticosteroid stimulation.

Research indicates PE-22-28 enhances neuronal excitability, synaptic communication, and neuroprotection through modulation of membrane-bound calcium channels and cholinergic signaling.
It has also been shown to influence learning, stress adaptation, and emotional regulation, making it a useful compound for studying ACTH-derived peptide signaling in the central nervous system.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of ACTH-derived neuropeptide function and receptor interactions

• Studies on neuroprotection, synaptic modulation, and cognitive signaling

• Research on peptide regulation of neuronal plasticity and stress response

• Analysis of calcium-channel activity and neurotransmitter release mechanisms