IGF-1 LR3

Description

IGF-1 LR3 (Insulin-Like Growth Factor-1 Long Arg3 / Extended Half-Life Analog)

Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₂₀S₉
Molecular Weight: 9,115 g/mol
Sequence: Gly-Pro-Glu-Glu-Thr-Leu-Cys-Gly-Ala-Gln-Pro-Leu-Val-Ser-Ala-Leu-Tyr-Gly-Phe-Tyr-Thr-Pro-Lys-Ala-Ser-Arg-Leu-Gly-Asp-Ile-Val-Gly-Ser-Arg-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala-Phe-Leu-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Pro-Thr-Ala-Ser-Arg-Arg-Leu-Pro-Gly-Glu
CAS Number: 946870-92-4
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

IGF-1 LR3 (Long Arg3 Insulin-Like Growth Factor 1) is a synthetic analog of human IGF-1 engineered for enhanced potency and extended half-life.
This peptide contains a substitution of Arg for Glu at position 3 and an additional 13-amino-acid N-terminal extension, which significantly reduces binding affinity to IGF-binding proteins (IGFBPs)—increasing its bioavailability and duration of action.

In research models, IGF-1 LR3 has been shown to stimulate muscle cell differentiation and proliferation, enhance protein synthesis, and promote cellular growth and recovery via activation of the PI3K/Akt and mTOR pathways.
Because it mimics the anabolic and regenerative signaling of native IGF-1 with greater stability, IGF-1 LR3 is widely used for metabolic, muscular, and growth-factor receptor signaling research.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of IGF-1 receptor signaling and anabolic pathway activation

• Studies on muscle cell proliferation, differentiation, and recovery mechanisms

• Research on insulin/IGF-axis regulation, mTOR activation, and protein synthesis

• Analysis of growth factor analogs with reduced IGFBP affinity and extended half-life