MGF

Description

MGF (Mechano Growth Factor / IGF-1 Ec Splice Variant)

Molecular Formula: C₃₃₂H₅₂₆N₉₂O₉₈S₇
Molecular Weight: 7,464 g/mol (approximate, varies by isoform)
Sequence: YQPPSTNKNTKSQRRKGSTFEERK
CAS Number: 88896-35-1
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

MGF (Mechano Growth Factor), also known as IGF-1 Ec, is a splice variant of the insulin-like growth factor-1 (IGF-1) gene expressed in response to mechanical overload or muscle damage.
This peptide corresponds to a unique E-domain sequence at the C-terminus of the IGF-1 precursor, giving it distinct autocrine/paracrine properties compared to systemic IGF-1.

Research indicates that MGF promotes satellite cell activation, muscle fiber repair, and localized hypertrophy without significantly affecting systemic metabolism.
By stimulating myoblast proliferation before differentiation, it plays a critical role in early-stage muscle regeneration and adaptation following mechanical stress or injury.

MGF is therefore a key experimental tool for studying mechanotransduction, muscle plasticity, and localized anabolic signaling distinct from IGF-1 LR3 and DES variants.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of IGF-1 gene splicing and localized anabolic signaling

• Studies on muscle fiber regeneration, hypertrophy, and mechanotransduction

• Research on satellite cell activation and myoblast proliferation

• Analysis of tissue-specific growth factor variants and temporal gene expression