PEG-MGF

Description

PEG-MGF (Pegylated Mechano Growth Factor / Long-Acting IGF-1 Ec Analog)

Molecular Formula: Variable (pegylated derivative of MGF; exact formula depends on PEG chain length)
Molecular Weight: ~8,000–10,000 g/mol (varies with PEG conjugation)
Sequence: YQPPSTNKNTKSQRRKGSTFEERK (MGF) with PEG polymer covalently linked to the N-terminus
CAS Number: Not assigned
Purity: ≥98 % (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

PEG-MGF (Pegylated Mechano Growth Factor) is a chemically modified analog of Mechano Growth Factor (IGF-1 Ec) in which a polyethylene glycol (PEG) chain is covalently attached to the peptide backbone to enhance stability, solubility, and plasma half-life.

This modification reduces enzymatic degradation and renal clearance, resulting in a prolonged duration of biological activity compared with native MGF.
PEG-MGF retains the biological activity of the parent peptide, promoting myoblast proliferation, satellite-cell activation, and muscle-fiber regeneration in experimental models of muscle stress or injury.

It provides an effective model for exploring growth-factor pharmacokinetics, peptide pegylation chemistry, and localized anabolic responses to mechanical or biochemical stimuli.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of pegylation effects on peptide stability and bioavailability

• Studies on muscle regeneration, hypertrophy, and satellite-cell activation

• Research on IGF-1 Ec–mediated growth signaling and tissue repair

• Analysis of pharmacokinetic improvements via polymer-peptide conjugation