Hexarelin

Description

Hexarelin (Growth Hormone Releasing Peptide / Ghrelin Receptor Agonist)

Molecular Formula: C₄₇H₅₈N₁₂O₆
Molecular Weight: 887.04 g/mol
Sequence: His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH₂
CAS Number: 140703-51-1
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20°C. Protect from light and moisture.

Description

Hexarelin is a synthetic hexapeptide belonging to the growth hormone–releasing peptide (GHRP) family and functions as a potent ghrelin receptor (GHSR-1a) agonist.
It is known for its robust and consistent stimulation of growth hormone (GH) secretion, exceeding that of earlier GHRPs such as GHRP-6 and GHRP-2.

Through activation of the GHSR-1a receptor, Hexarelin promotes pituitary GH release via phospholipase C–mediated calcium signaling, resulting in a pronounced increase in circulating GH and IGF-1 levels.
Preclinical studies also suggest additional benefits in cardiovascular protection, myocardial regeneration, and lipid metabolism, making Hexarelin a versatile research model for endocrine and metabolic regulation.

Hexarelin’s strong GH-releasing potency and consistent pharmacokinetic profile make it useful for investigating dose-dependent GH pulsatility and synergistic activity when paired with GHRH analogs such as CJC-1295 or Sermorelin.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of GHSR-1a activation and pituitary GH release mechanisms

• Studies on GH/IGF-1 signaling and metabolic regulation

• Research on cardiovascular protection and myogenic regeneration

• Analysis of synergistic GH-releasing effects with GHRH analogs