AOD-9604

Description

AOD-9604 (Fragment 176–191 of Human Growth Hormone / Lipolytic and Metabolic Peptide)

Molecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂
Molecular Weight: 1,814.08 g/mol
Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Gly-Ser-Cys-Gly-Phe
CAS Number: 221231-10-3
Purity: ≥ 98 % (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

AOD-9604 (Advanced Obesity Drug 9604) is a synthetic 15-amino-acid fragment of the C-terminal region of human growth hormone (hGH 176–191) that retains the lipolytic and anti-adipogenic properties of native hGH without stimulating IGF-1 or growth activity.

Mechanistically, AOD-9604 activates β-adrenergic and hormone-sensitive lipase pathways, enhancing fatty-acid oxidation and triglyceride breakdown in adipose tissue.
It also appears to promote lipid mobilization and improve energy expenditure via cAMP-dependent signaling while sparing lean tissue mass.

This peptide is widely utilized in metabolic research investigating obesity, lipid metabolism, and mitochondrial substrate utilization, serving as a non-anabolic model for GH-mediated fat loss mechanisms.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of GH-fragment–induced lipolysis and β-oxidation

• Studies on adipocyte metabolism and energy-balance regulation

• Research on lipid mobilization without IGF-1 elevation

• Analysis of mitochondrial substrate utilization and metabolic efficiency