Thymosin Alpha-1

Description

Thymosin Alpha-1 (Tα1) (Immunomodulatory Peptide / Thymic-Derived Immune Regulator)

Molecular Formula: C₁₂₉H₂₁₅N₃₃O₅₅
Molecular Weight: 3,107.35 g/mol
Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH
CAS Number: 14636-12-5
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20°C. Protect from light and moisture.

Description

Thymosin Alpha-1 (Tα1) is a 28-amino-acid thymic peptide originally isolated from thymosin fraction 5, known for its potent role in immune modulation, T-cell differentiation, and host defense regulation.

Tα1 acts primarily by enhancing T-lymphocyte maturation and activation, promoting Th1 cytokine responses, and improving antigen presentation through upregulation of MHC class I expression.
It also exhibits anti-inflammatory and cytoprotective properties, balancing immune activity under conditions of chronic inflammation, infection, or immune suppression.

Research applications of Thymosin Alpha-1 span immunology, oncology, and infectious disease, where it has been shown to influence dendritic cell signaling, toll-like receptor pathways, and interferon modulation.
Due to its broad immunoregulatory profile, it serves as a key model peptide for exploring immune restoration and adaptive response mechanisms.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of T-cell activation and immune system modulation

• Studies on cytokine signaling, toll-like receptor pathways, and antigen presentation

• Research on anti-inflammatory and immunorestorative processes

• Analysis of thymic peptide roles in immune balance and cellular defense