5-Amino-1MQ

Description

5-Amino-1MQ (NNMT Inhibitor / NAD⁺ Metabolism Modulator)

Molecular Formula: C₇H₁₀N₂O
Molecular Weight: 138.17 g/mol
CAS Number: 252331-84-7
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20°C. Protect from light and moisture.

Description

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), a key enzyme that regulates methylation balance and NAD⁺ metabolism.
By inhibiting NNMT, 5-Amino-1MQ helps preserve intracellular nicotinamide and methyl donor pools, enhancing NAD⁺ availability and promoting cellular energy efficiency.

Preclinical studies have demonstrated that 5-Amino-1MQ increases lipolysis, reduces adipocyte size, and enhances metabolic rate, making it a valuable model compound for research on obesity, insulin sensitivity, and mitochondrial function.
It has also been investigated for its role in epigenetic regulation and sirtuin activation through modulation of methyl donor utilization pathways.

Due to its bioavailability and robust impact on methylation flux, 5-Amino-1MQ serves as a key tool for exploring metabolic optimization, NAD⁺ homeostasis, and anti-aging mechanisms in cellular and organismal models.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of NNMT inhibition and methylation metabolism

• Studies on NAD⁺ recycling, mitochondrial efficiency, and sirtuin signaling

• Research on adipocyte metabolism, fat oxidation, and insulin response

• Analysis of metabolic regulation and cellular bioenergetics