AICAR

Description

AICAR (AMPK Activator / Metabolic Regulator Compound)

Molecular Formula: C₉H₁₅N₄O₈P 
Molecular Weight: ~ 338.21 g/mol
Sequence: Not applicable (nucleotide-analogue)
CAS Number: 2627-69-2
Purity: ≥98% (HPLC, supplier specification)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

AICAR is a synthetic nucleotide-analogue that mimics AMP and acts as a potent activator of the AMP‑activated protein kinase (AMPK) — a key energy-sensor enzyme in cells. 
It is widely used in research to explore cellular energy homeostasis, metabolic regulation, mitochondrial biogenesis, and fat oxidation.

Within experimental models:

• AICAR has been shown to increase glucose uptake, enhance fatty-acid oxidation, and promote mitochondrial adaptation via AMPK activation.

• It has also been explored for endurance enhancement in animal models (e.g., mimicking exercise effects) and metabolic disease modulation. 

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic purposes.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of AMPK-mediated metabolic and energy pathways

• Studies on fat oxidation, glucose uptake, insulin sensitivity, and mitochondrial biogenesis

• Research on exercise-mimetic compounds and metabolic adaptation

• Analysis of mitochondrial health, cellular stress responses, and metabolic disease models