Epitalon

Description

Epitalon (Epithalamin) (Telomerase Activator / Pineal-Derived Longevity Peptide)

Molecular Formula: C₁₄H₂₂N₄O₉
Molecular Weight: 390.35 g/mol
Sequence: Ala-Glu-Asp-Gly
CAS Number: 307297-39-8
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20°C. Protect from light and moisture.

Description

Epitalon (also known as Epithalamin) is a synthetic tetrapeptide derived from the naturally occurring epiphyseal polypeptide Epithalamin, originally isolated from the pineal gland.
It is a bioregulatory peptide recognized for its ability to activate telomerase, extend telomere length, and promote cellular longevity through genomic stabilization mechanisms.

Epitalon regulates gene expression related to DNA repair, antioxidant defense, and circadian rhythm synchronization, contributing to improved cellular homeostasis and stress resistance.
Preclinical research has demonstrated its influence on melatonin secretion, immune system modulation, and oxidative stress reduction, positioning it as a model compound for studies in aging, regeneration, and chronobiology.

Mechanistically, Epitalon functions through the stimulation of telomerase reverse transcriptase (TERT) expression and enhancement of chromosomal telomere repair, delaying cellular senescence.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of telomerase activation and telomere elongation mechanisms

• Studies on genomic stability, oxidative stress resistance, and anti-senescence signaling

• Research on circadian rhythm regulation and pineal peptide bioregulation

• Analysis of longevity, neuroendocrine, and regenerative processes