FOX04

Description

FOXO4-DRI (FOXO4-p53 Interaction Inhibitor / Senolytic Peptide)

Molecular Formula: C₂₁₅H₃₂₈N₆₄O₆₆S
Molecular Weight: 4,786.4 g/mol
Sequence: H-Arg-Ala-Ser-Ser-Leu-Ile-Asp-Gln-Thr-Leu-Arg-Lys-Ile-Ser-Arg-Lys-Leu-Phe-Ser-Asp-Asp-Lys-Leu-Lys-Gln-Asp-Leu-Tyr-Arg-Ala-Ala-Ala-Leu-Glu-Asp-Leu-Phe-NH₂ (D-retro-inverso configuration)
CAS Number: 2084312-52-4
Purity: ≥98 % (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

FOXO4-DRI is a synthetic D-retro-inverso peptide derived from the forkhead box O4 (FOXO4) protein sequence.
It is engineered to disrupt the interaction between FOXO4 and p53, selectively inducing apoptosis in senescent cells while sparing healthy proliferating cells.

This compound provides a powerful research tool for exploring cellular senescence, tissue regeneration, and aging biology.
By modulating the FOXO4–p53 nuclear retention axis, FOXO4-DRI facilitates studies on senolytic mechanisms, DNA-damage responses, and pro-survival signaling suppression within aged or stressed cell populations.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of FOXO4–p53 signaling and cellular senescence pathways

• Studies on selective senolytic activity and apoptosis induction

• Research on tissue regeneration, aging, and longevity mechanisms

• Analysis of pro-survival signaling and mitochondrial stress responses