GHRP-6

Description

GHRP-6 (Growth Hormone Releasing Peptide-6 / Ghrelin Receptor Agonist)

Molecular Formula: C₄₆H₅₆N₁₂O₆
Molecular Weight: 873.0 g/mol
Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂
CAS Number: 87616-84-0
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20°C. Protect from light and moisture.

Description

GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide that functions as a potent ghrelin receptor (GHSR-1a) agonist, stimulating growth hormone (GH) secretion from the anterior pituitary.
It activates the GH secretagogue pathway independently of GHRH, promoting calcium mobilization and pituitary signal transduction to induce strong, pulsatile GH release.

GHRP-6 is notable for its secondary effect of enhancing appetite and gastric motility due to ghrelin-mimetic activity, making it a key compound for investigating energy balance and metabolic adaptation in preclinical models.
It also supports research into muscle recovery, tissue regeneration, and lipid metabolism, with GH/IGF-1 axis upregulation serving as a primary mechanistic pathway.

When co-administered with CJC-1295 or Ipamorelin, GHRP-6 demonstrates synergistic GH pulse amplitude enhancement and extended downstream IGF-1 elevation.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of GH secretagogue receptor (GHSR-1a) activation

• Studies on GH/IGF-1 axis regulation and pulsatile hormone secretion

• Research on appetite control, metabolism, and energy homeostasis

• Analysis of ghrelin analogs and endocrine response modulation