HMG

Description

HMG (Human Menopausal Gonadotropin / FSH & LH Combination Glycoprotein Hormone)

Approximate Conversion:
1 IU ≈ 0.01 mg (10 µg)
Therefore: 75 IU ≈ 0.75 mg total active hormone content (FSH + LH)

Molecular Formula: Variable (glycoprotein complex)
Molecular Weight: ~30,000–35,000 g/mol (dimeric form)
Composition: Follicle-Stimulating Hormone (FSH) + Luteinizing Hormone (LH), typically 1:1 ratio
CAS Number: 9002-68-0
Purity: ≥95% (Bioassay-calibrated by WHO IU standard)
Form: Lyophilized Powder
Storage: Store at 2–8 °C. Protect from light and moisture.

Description

Human Menopausal Gonadotropin (HMG) is a naturally derived glycoprotein hormone complex containing both FSH (Follicle-Stimulating Hormone) and LH (Luteinizing Hormone).
It is isolated from the urine of postmenopausal women, purified, and standardized by biological potency (IU) rather than mass, due to variable glycosylation states that influence activity.

In research applications, HMG is used to study gonadal steroidogenesis, follicular maturation, spermatogenesis, and pituitary–gonadal axis regulation.
The FSH component primarily stimulates ovarian follicle and Sertoli cell development, while the LH component promotes ovulation and Leydig cell androgen synthesis.

This dual action makes HMG a key reagent for exploring hormonal regulation, receptor signaling, and fertility-related endocrinology in in vitro and in vivo systems.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of FSH and LH receptor activation and signaling pathways

• Studies on folliculogenesis, spermatogenesis, and steroid hormone production

• Research on gonadal endocrine feedback and pituitary regulation

• Analysis of glycoprotein hormone bioactivity and receptor cross-reactivity