IGF-1 DES

Description

IGF-1 DES(1–3) (Insulin-Like Growth Factor-1 Truncated Analog / Potent IGF-1R Agonist)

Molecular Formula: C₃₃₂H₅₂₆N₉₂O₉₈S₇
Molecular Weight: 7,464 g/mol
Sequence: Tyr-Gly-Ser-Ser-Ser-Arg-Gly-Phe-Tyr-Thr-Pro-Lys-Ala-Ser-Arg-Leu-Gly-Asp-Ile-Val-Gly-Ser-Arg-Glu-Cys-Cys-Phe-Arg-Ser-Cys-Asp-Leu-Arg-Arg-Leu-Met-Tyr-Cys-Ala-Pro-Leu-Lys-Pro-Ala-Lys-Ser-Ala-Phe-Leu-Lys-Pro-Thr-Gly-Tyr-Gly-Ser-Ser-Ser-Arg-Arg-Ala-Pro-Pro-Thr-Ala-Ser-Arg-Arg-Leu-Pro-Gly-Glu
CAS Number: 946870-90-2
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

IGF-1 DES(1–3) is a truncated analog of human insulin-like growth factor-1 (IGF-1), lacking the first three N-terminal amino acids.
This modification prevents binding to IGF-binding proteins (IGFBPs), resulting in a markedly higher bioactive potency—up to 10-fold greater than native IGF-1 in some experimental systems.

IGF-1 DES(1–3) activates the IGF-1 receptor (IGF-1R) to initiate PI3K/Akt and MAPK signaling cascades, promoting cell proliferation, differentiation, and survival.
Due to its shorter half-life and local action profile, it is especially suited for studies on localized tissue growth, muscle regeneration, and cellular anabolic signaling where transient receptor activation is desired.

This analog serves as a valuable model for investigating growth factor receptor pharmacology, IGFBP-independent signaling, and tissue-specific anabolic processes.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of IGF-1 receptor activation and downstream anabolic pathways

• Studies on local tissue growth, muscle regeneration, and repair mechanisms

• Research on IGFBP-independent IGF signaling and receptor desensitization

• Analysis of growth factor truncation effects on receptor affinity and signal duration