Kisspeptin-10

Description

Kisspeptin-10 (Metastin Fragment / Hypothalamic GnRH Axis Activator)

Molecular Formula: C₆₃H₈₃N₁₇O₁₃S
Molecular Weight: 1302.48 g/mol
Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
CAS Number: 327414-93-5
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

Kisspeptin-10 is a bioactive decapeptide fragment derived from the larger Kisspeptin (metastin) precursor, encoded by the KISS1 gene.
It acts as a potent agonist of the G-protein-coupled receptor GPR54 (also known as KISS1R), serving as a key regulator of the hypothalamic-pituitary-gonadal (HPG) axis.

Kisspeptin-10 stimulates the release of gonadotropin-releasing hormone (GnRH) from hypothalamic neurons, leading to increased secretion of LH and FSH in downstream pituitary targets.
This makes it a crucial model for research on pubertal onset, reproductive endocrinology, and neuroendocrine feedback mechanisms.

In addition to its reproductive role, emerging data highlight its involvement in energy metabolism, stress response, and placental signaling, providing new insights into hormonal homeostasis and fertility regulation.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of hypothalamic GnRH release and reproductive axis activation

• Studies on LH/FSH modulation and gonadal signaling pathways

• Research on puberty onset, fertility control, and endocrine feedback loops

• Analysis of kisspeptin receptor (GPR54/KISS1R) signaling and gene regulation