KPV

Description

KPV (Lys-Pro-Val Tripeptide / Melanocortin-Derived Anti-Inflammatory Peptide)

Molecular Formula: C₁₆H₃₁N₅O₄
Molecular Weight: 357.46 g/mol
Sequence: Lys-Pro-Val
CAS Number: 86917-16-6
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

KPV is a naturally derived tripeptide fragment of α-melanocyte-stimulating hormone (α-MSH) that exhibits potent anti-inflammatory and immunomodulatory activity.
It acts primarily through melanocortin-1 receptor (MC1R) signaling and NF-κB pathway suppression, making it a valuable model for studying peptide-mediated inflammation control, epithelial repair, and barrier function.

Preclinical research demonstrates that KPV can inhibit pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, while promoting wound healing and mucosal integrity in epithelial tissues.
Its minimal sequence and high stability make it a preferred candidate for mechanistic studies on melanocortin-derived peptides and localized immune regulation.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of melanocortin receptor signaling and NF-κB suppression

• Studies on anti-inflammatory and immunomodulatory peptides

• Research on epithelial healing and barrier integrity mechanisms

• Analysis of cytokine inhibition and wound-repair pathways