Letrozole

Description

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Letrozole (Non-Steroidal Aromatase Inhibitor / Estrogen Synthesis Modulator)

Form: Tablet
Concentration: 2.5 mg per tablet
Quantity per Bottle: 30 tablets

Molecular Formula: C₁₇H₁₁N₅
Molecular Weight: 285.31 g/mol
CAS Number: 112809-51-5
Purity: ≥98% (HPLC)
Storage: Store in a cool, dry place away from light and moisture.

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Description

Letrozole is a non-steroidal triazole derivative that functions as a potent aromatase (CYP19A1) enzyme inhibitor, suppressing the conversion of androgens to estrogens.
In experimental endocrinology, Letrozole is used to study estrogen regulation, hypothalamic-pituitary feedback mechanisms, and androgen–estrogen balance.

Research has shown that inhibition of aromatase by Letrozole can increase circulating testosterone levels, reduce estrogen-dependent feedback, and modulate gonadotropin secretion (LH/FSH).
It is widely used as a model compound for studying endocrine suppression, post-cycle hormone dynamics, and estrogen-sensitive signaling in both reproductive and metabolic systems.

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Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

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Key Research Applications

• Investigation of aromatase inhibition and estrogen synthesis suppression

• Studies on androgen–estrogen homeostasis and hormonal feedback control

• Research on pituitary gonadotropin modulation and testosterone regulation

• Analysis of endocrine resistance and estrogen receptor–dependent signaling