MOTS-C

Description

MOTS-c (Mitochondrial-Derived Peptide / Metabolic Regulator & AMPK Activator)

Molecular Formula: C₁₉₀H₂₉₄N₅₂O₅₄S
Molecular Weight: 2,137.40 g/mol
Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Gln-Glu-Arg
CAS Number: 1474307-69-9
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20°C. Protect from light and moisture.

Description

MOTS-c (Mitochondrial ORF of the 12S rRNA type-c) is a naturally occurring peptide encoded within the mitochondrial genome, functioning as a cellular energy sensor and metabolic regulator.
It plays a central role in maintaining metabolic homeostasis, insulin sensitivity, and cellular resilience under stress.

Mechanistically, MOTS-c activates AMP-activated protein kinase (AMPK), a master regulator of energy metabolism, promoting fatty acid oxidation, glucose uptake, and mitochondrial biogenesis.
It also supports nuclear–mitochondrial communication, allowing adaptive responses to nutrient stress and oxidative imbalance.

Research shows MOTS-c influences:

• Energy expenditure and metabolic flexibility

• Insulin signaling and glucose homeostasis

• Skeletal muscle performance and mitochondrial turnover

• Cellular protection under oxidative and genotoxic stress

Its broad metabolic and cytoprotective effects make it a key peptide for studying metabolic syndrome, aging, and mitochondrial optimization.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of AMPK activation and mitochondrial bioenergetic control

• Studies on metabolic homeostasis and insulin sensitivity mechanisms

• Research on oxidative stress adaptation and cellular longevity

• Analysis of mitochondrial peptides in exercise physiology and metabolic health