NAD⁺

Description

NAD⁺ (Nicotinamide Adenine Dinucleotide / Cellular Energy Cofactor & Redox Modulator)

Concentration: 500 mg/vial
Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
Molecular Weight: 663.43 g/mol
CAS Number: 53-84-9
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20°C. Protect from light and moisture.

Description

NAD⁺ (Nicotinamide Adenine Dinucleotide) is a universal redox coenzyme central to cellular energy metabolism, mitochondrial respiration, and oxidative stress regulation.
It functions as an essential electron carrier in oxidation-reduction reactions, particularly in glycolysis, the TCA cycle, and oxidative phosphorylation, enabling efficient ATP generation.

In addition to its metabolic roles, NAD⁺ serves as a substrate for sirtuins (SIRT1–7), PARPs (poly ADP-ribose polymerases), and CD38, linking it directly to DNA repair, longevity signaling, and cellular stress response.

Preclinical research shows that NAD⁺ replenishment enhances:

• Mitochondrial biogenesis and function

• Sirtuin-mediated gene regulation and metabolic efficiency

• Cellular resilience to oxidative and genotoxic stress

• Neuroprotective and anti-aging mechanisms

NAD⁺ is often studied alongside NMN, NR, and MOTS-c in mitochondrial and aging-related research due to its pivotal role in bioenergetics and redox homeostasis.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of mitochondrial energy metabolism and ATP production

• Studies on NAD⁺-dependent sirtuin activation and longevity pathways

• Research on oxidative stress resistance and DNA repair mechanisms

• Analysis of redox balance and metabolic aging models