PNC-27

Description

PNC-27 (HDM-2 Binding / Selective Oncolytic Peptide)

Molecular Formula: C₁₄₉H₂₂₉N₄₅O₄₂
Molecular Weight: 3,204.6 g/mol
Sequence: H-Met-Ala-Gly-Gly-Gly-Ala-Gly-Gly-Gly-Gly-Thr-Leu-Thr-Phe-Thr-Ser-Glu-Gly-Thr-Leu-Leu-Gly-Leu-Ala-Pro-Phe-Ser-Pro-Phe-NH₂
CAS Number: 517909-22-7
Purity: ≥98 % (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

PNC-27 is a synthetic chimeric peptide engineered to selectively induce cell-membrane disruption in cancer cells by targeting HDM-2 (Human Double Minute-2) — a negative regulator of the p53 tumor-suppressor protein.

The peptide contains an HDM-2–binding domain derived from p53 (residues 12–26) fused to a cell-penetrating leader sequence (membrane-active segment of MRP).
Preclinical research has shown that PNC-27 binds HDM-2 expressed on the plasma membranes of malignant cells, forming transmembrane pores that lead to selective necrosis or apoptosis of tumor cells, while sparing normal, non-HDM-2–expressing cells.

Because of this selectivity, PNC-27 is widely used in oncology and membrane biophysics research as a model for targeted peptide-induced cytotoxicity, p53 pathway restoration, and HDM-2–mediated cancer biology.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of HDM-2–mediated tumor selectivity and p53-related pathways

• Studies on peptide-induced membrane pore formation and cytolytic activity

• Research on targeted oncolytic peptides and cancer-cell apoptosis mechanisms

• Analysis of selective cytotoxicity and tumor-specific receptor binding