PT-141

Description

PT-141 (Bremelanotide / Melanocortin Receptor Agonist)

Molecular Formula: C₅₀H₆₈N₁₄O₁₀
Molecular Weight: 1,024.18 g/mol
Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
CAS Number: 189691-06-3
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide that functions as a potent melanocortin receptor agonist, primarily targeting MC3R and MC4R receptors within the central nervous system.
It is derived from the Melanotan II backbone but engineered to emphasize neurogenic effects rather than peripheral pigmentation activity.

In research settings, PT-141 is used to investigate neuroendocrine signaling, sexual arousal pathways, and hypothalamic modulation of autonomic function.
Through activation of melanocortin receptors, it provides a model for exploring CNS-mediated physiological responses, including those linked to energy homeostasis, cardiovascular tone, and reproductive neurochemistry.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic use.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of melanocortin receptor signaling (MC3R, MC4R) in CNS pathways

• Studies on hypothalamic control of sexual behavior and arousal mechanisms

• Research on neuropeptide regulation of energy expenditure and appetite

• Analysis of structure–activity relationships among melanocortin analogs