P21

Description

P21 (Nootropic / Neural Regeneration Peptide)

Molecular Formula: C₆₃H₁₀₁N₁₇O₁₅
Molecular Weight: 1,344.6 g/mol
Sequence: Ala-Gly-Asp-Ala-Ser-Gly-Pro-Pro-Gly-Lys-Lys-Lys-Arg-Lys-Leu-Ala
CAS Number: 1178199-15-1
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

P21 is a synthetic neurotrophic peptide derived from the C-terminal fragment of ciliary neurotrophic factor (CNTF) and modified to enhance blood-brain barrier permeability and metabolic stability.
It is a research compound of growing interest for studying neuronal differentiation, synaptic plasticity, and neurogenesis.

P21 has been shown in preclinical models to upregulate brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression, while supporting neuronal survival and regeneration following injury or degenerative stress.
Its mechanism is believed to involve activation of the CNTF receptor complex and downstream JAK/STAT and MAPK signaling pathways, providing a valuable model for exploring peptide-induced neurorestorative processes.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of neurotrophic and neuroprotective peptide signaling

• Studies on BDNF and NGF expression and synaptic plasticity

• Research on neural regeneration and CNS repair mechanisms

• Analysis of CNTF receptor–mediated cell survival pathways