Semax

Description

Semax (ACTH(4–10) Analog / Neuroprotective Nootropic Peptide)

Molecular Formula: C₃₇H₅₁N₉O₁₀
Molecular Weight: 753.9 g/mol
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
CAS Number: 80714-61-0
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20 °C. Protect from light and moisture.

Description

Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH(4–10)) engineered to produce neurotrophic, nootropic, and neuroprotective effects without affecting corticosteroid secretion.

Research indicates that Semax promotes upregulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), enhances synaptic plasticity, and supports cognitive performance under conditions of stress or ischemia.
It has also been shown to modulate the dopaminergic, serotonergic, and glutamatergic systems, providing a valuable model for studying peptide-induced neural adaptation and central nervous system resilience.

Preclinical studies show that Semax activates cAMP, MAPK/ERK, and CREB pathways associated with learning, neuroprotection, and cellular repair.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of ACTH-derived peptide signaling and neurotrophic pathways

• Studies on BDNF/NGF upregulation and synaptic plasticity

• Research on stress response modulation and ischemic neuroprotection

• Analysis of peptide-based cognitive enhancement and CNS repair mechanisms