Sermorelin

Description

Sermorelin (Growth Hormone Releasing Hormone Analog / GHRH 1–29 Peptide)

Molecular Formula: C₁₅₁H₂₅₂N₄₄O₄₅S
Molecular Weight: 3,358.9 g/mol
Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂
CAS Number: 86168-78-7
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20°C. Protect from light and moisture.

Description

Sermorelin is a synthetic 29–amino acid peptide fragment corresponding to the N-terminal region of endogenous Growth Hormone Releasing Hormone (GHRH).
It acts as a pituitary GHRH receptor agonist, stimulating physiological growth hormone (GH) release through the hypothalamic-pituitary axis.

Unlike GHRPs, which act via ghrelin receptors, Sermorelin directly mimics natural GHRH activity—initiating calcium-dependent cAMP signaling and promoting pulsatile GH secretion without overstimulation.
This makes it an ideal research compound for studying GH axis regulation, endocrine feedback mechanisms, and IGF-1 synthesis in preclinical settings.

Sermorelin is frequently compared or co-administered with CJC-1295 to explore half-life extension and GH pulse amplitude in experimental protocols involving GH/IGF-1 axis modulation.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of GHRH receptor activation and pituitary GH release

• Studies on GH/IGF-1 axis modulation and endocrine signaling

• Research on pulsatile GH secretion and hypothalamic feedback mechanisms

• Analysis of age-related decline in GH output and receptor responsiveness