Tadalafil

Description

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Tadalafil (Phosphodiesterase Type 5 Inhibitor / cGMP Pathway Modulator)

Form: Tablet
Concentration: 20 mg per tablet
Quantity per Bottle: 30 tablets

Molecular Formula: C₂₂H₁₉N₃O₄
Molecular Weight: 389.41 g/mol
CAS Number: 171596-29-5
Purity: ≥98% (HPLC)
Storage: Store in a cool, dry place away from light and moisture.

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Description

Tadalafil is a selective phosphodiesterase type 5 (PDE5) inhibitor that enhances cyclic guanosine monophosphate (cGMP) signaling by preventing its enzymatic degradation.
It is widely used in research exploring nitric oxide–mediated vasodilation, smooth muscle relaxation, and endothelial function.

Through PDE5 inhibition, Tadalafil promotes vascular relaxation and increased blood flow in smooth muscle tissues, particularly within the corpus cavernosum and vascular endothelium.
It has also been used as a model compound in studies investigating pulmonary hypertension, exercise performance, and vascular signaling pathways related to nitric oxide and cGMP activity.

Its longer half-life (≈17.5 hours) compared to similar compounds like Sildenafil or Vardenafil makes it ideal for extended research on chronic vascular modulation and endothelial responsiveness.

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Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

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Key Research Applications

• Investigation of PDE5 inhibition and cGMP signal transduction

• Studies on nitric oxide–mediated vasodilation and endothelial regulation

• Research on smooth muscle relaxation and vascular tone modulation

• Comparative pharmacokinetic analysis of PDE5 inhibitors in vascular models