TB-500 (Thymosin Beta-4 Fragment)
Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight: 4,963.44 g/mol
CAS Number: 77591-33-4
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20°C. Protect from light and moisture.
Description
TB-500 is a synthetic fragment of Thymosin Beta-4, a naturally occurring peptide involved in cellular migration, tissue repair, and regenerative signaling. It is widely studied for its role in actin regulation, which is essential for cell structure, movement, and intracellular transport.
Through its actin-binding properties, TB-500 facilitates cytoskeletal remodeling and enhances cellular motility, enabling efficient migration of repair cells to sites of injury. It has been shown to upregulate vascular endothelial growth factor (VEGF), supporting angiogenesis and improved blood supply to damaged tissues.
Additionally, TB-500 promotes fibroblast activity and extracellular matrix remodeling, both critical processes in wound healing and structural tissue repair. Its systemic distribution properties make it a valuable model for studying whole-body regenerative mechanisms rather than localized effects alone.
This peptide serves as a powerful research tool for investigating multi-pathway healing processes, including inflammation modulation, tissue regeneration, and cellular differentiation.
Intended Use
This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.
Key Research Applications
- Investigation of actin-mediated cellular migration and repair
- Studies on angiogenesis and VEGF signaling pathways
- Research on fibroblast activity and extracellular matrix remodeling
- Analysis of systemic vs. localized tissue regeneration models
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