Tesamorelin

Description

Tesamorelin (Synthetic GHRH Analog / Growth Hormone Secretagogue)

Molecular Formula: C₂₂₁H₃₆₆N₇₂O₆₇S
Molecular Weight: 5,006.36 g/mol
Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Gln-Ser-Asn-Gln-Glu-Glu-Lys-Glu-Glu-Glu-Tyr-Leu-Glu-Asn-Gln-Glu-Gln-Lys-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Glu-Gln-Gлу… (truncated; 44-amino-acid analog of GHRH 1–44)
CAS Number: 218949-48-5
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: Store at −20°C. Protect from light and moisture.

Description

Tesamorelin is a synthetic analog of Growth Hormone Releasing Hormone (GHRH 1–44) engineered for increased stability, receptor affinity, and half-life compared to endogenous GHRH.
It functions as a pituitary GHRH receptor agonist, inducing pulsatile GH release and subsequent IGF-1 elevation, making it an ideal compound for studying somatotropic axis modulation.

Through its extended half-life and selective receptor activation, Tesamorelin allows consistent evaluation of GH-dependent metabolic and anabolic effects, including lipid mobilization, fat oxidation, and muscle tissue maintenance.
Preclinical research has demonstrated pronounced effects on visceral adiposity reduction, mitochondrial metabolism, and protein synthesis pathways via IGF-1 mediated signaling.

Compared to shorter GHRH analogs like Sermorelin, Tesamorelin’s stabilized structure provides prolonged receptor activation and a more sustained GH pulse profile, making it valuable for endocrine and metabolic research.

Intended Use

This product is intended for laboratory research use only.
It is not for human consumption, diagnostic, or therapeutic applications.
All handling should be performed by qualified professionals in a controlled research environment.

Key Research Applications

• Investigation of GHRH receptor activation and GH pulsatility

• Studies on IGF-1 axis regulation and metabolic rate modulation

• Research on lipid metabolism, adipose reduction, and lean mass preservation

• Analysis of peptide stability and long-acting endocrine analog design